
5 years ago
Liu and Damania Labs identified new proteins controlling cGAS activation
Hyperactivation of innate immunity results in autoimmune diseases, while deficiency in innate immunity is prone to tumorigenesis. Thus, the activity of innate immune signaling is tightly controlled but the regulatory mechanisms have not been fully elucidated. Recently, the labs of Liu and Damania published a study in iScience revealing a role of the bacterial protein streptavidin in binding and facilitating cGAS activation.