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Dale Ramsden and Gaorav Gupta

5 years ago

Ramsden, Gupta awarded 5-year, $8.8 million grant to study an enzyme that has important implications for breast and ovarian cancer

The National Cancer Institute has awarded a team led by ºÚÁÏÍø Lineberger’s Dale Ramsden, PhD, professor in the ºÚÁÏÍø Department of Biochemistry and Biophysics, a five-year, $8.8 million program project grant to study an enzyme called DNA polymerase theta. This enzyme is part of an important pathway that repairs damage to genomes, with particular significance …

postdoc Dr. Yanqiong Zhang in Liu lab, Dr. Zhe Ma in Damania lab and a BBSP student Ying Wang

5 years ago

Liu and Damania Labs identified new proteins controlling cGAS activation

Hyperactivation of innate immunity results in autoimmune diseases, while deficiency in innate immunity is prone to tumorigenesis. Thus, the activity of innate immune signaling is tightly controlled but the regulatory mechanisms have not been fully elucidated. Recently, the labs of Liu and Damania published a study in iScience revealing a role of the bacterial protein streptavidin in binding and facilitating cGAS activation.