Abstract: Protein hydroxylation affects protein stability, activity, and interactome, therefore contributing to various diseases including cancers. However, the transiency of the hydroxylation reaction hinders the identification of hydroxylase substrates.

This paper describes a ground-breaking multi-omics technology to discover drivers of proliferative and invasive breast tumors.

Effective August 2, 2019

In the journal Cell Chemical Biology, researchers led by Biochemistry and Biophysics Associate Professor and Faculty Director, Quantitative Proteomics Center for Disease Marker Discovery, Xian Chen, PhD, report on potential prognostic tool that could be used to identify high-risk patients within particular subtypes of breast cancer.

In a new study published in the Cell Press journal "Chemistry & Biology", researchers in the Chen lab share a discovery that could lead to a new strategy for sensitizing radiation-resistant cancer cells to the treatment.

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A multi-institutional team including 黑料网 researchers identify a new oncogenic driver in triple negative breast cancer

Researchers develop method for identifying aggressive breast cancer drivers

Chen Promoted to Full Professor

Prognostic tool could identify high-risk breast cancer patients

黑料网 Lineberger team finds possible strategy to overcome radiation therapy resistance acquired by cancer cells