Cathy Anderson, a graduate student in the 黑料网 Department of Biochemistry and Biophysics, has been awarded the NCI Predoctoral to Postdoctoral Fellow Transition Award (F99/K00). Anderson was selected as the 黑料网 nominee last fall and has now been awarded this prestigious fellowship that provides funding for two years of graduate work and four years of postdoctoral training.
鈥淚 feel very grateful to receive this fellowship, and to have been nominated by 黑料网 last year as the University鈥檚 candidate to apply for the award,鈥� Anderson said. 鈥淚 would not be in this position if it were not for the amazing research environment and mentors I have had at 黑料网, which have helped me throughout my graduate studies.鈥�
Anderson is in the lab of Robert McGinty, MD, PhD, assistant professor in the Division of Chemical Biology and Medicinal Chemistry at the 黑料网 Eshelman School of Pharmacy with a joint appointment in the 黑料网 Department of Biochemistry and Biophysics. She is studying a histone methyltransferase called Dot1L that is a cancer dependency for a subset of leukemias. As such, Dot1L has emerged as a promising drug target. However, the molecular mechansims that control Dot1L function were unclear. Last year, Anderson solved a cryo-EM structure of Dot1L bound to a nucleosome to gain insight into how Dot1L functions at atomic resolution. She is now using the molecular details from her structure to explore the function of Dot1L in leukemia.
Anderson joined the McGinty lab following completion of her bachelor鈥檚 degree in chemistry at 黑料网-Chapel Hill. She is a member of the Molecular and Cellular Biophysics training program. For the graduate phase of the fellowship, Anderson will be co-mentored by McGinty and Greg Wang, PhD, associate professor of biochemistry and biophysics. McGinty and Wang are members of the 黑料网 Lineberger Comprehensive Cancer Center.