Professor; Core Director, Macromolecular Interactions Facility
HONORS AND AWARDS
- 2014 invited talk, Resources at the Macromolecular Interactions Facility, Structural Biology Symposium at 黑料网.
- 2013 invited talk, Resources at the Macromolecular Interactions Facility, Carolina center for Genome Sciences Spring Symposium, 鈥淔rom Genome to Proteome: Proteomic Innovations and Technologies at 黑料网.
- 2011, 2009, 2005, 2004 NIH Scientific Review committee member
RESEARCH
Dr. Tripathy is the Director of the Macromolecular Interactions Facility, a core facility of the University of North Carolina at Chapel Hill, which provides instrumentation and resources for biophysical characterization of biological macromolecules and their interactions with cognate ligands. Research applications include:
- Determination of solution molecular weight, oligomeric state and association/dissociation constants of macromolecules
- Determination of on and off rates (kon and koff), stoichiometry, equilibrium binding constants and other thermodynamic parameters (鈭咷, 鈭咹 and 鈭哠) of bimolecular interactions
- Determination of sedimentation, diffusion and frictional coefficients, hydrodynamic and RMS radius, and second virial coefficient
- Determinations of secondary structure, melting profile, melting temperature (Tm) and thermal stability
Dr. Tripathy provides training to faculty, post-docs, and students in experimental design, instrument operation, data analysis and interpretation one-on-one basis and through his 鈥淢acromolecular Interaction鈥� (BIOC662) course, a critical component of the Biophysics Training Program at 黑料网 and open to all graduate students.
